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Founded in 1811, Massachusetts General Hospital is the earliest and largest teaching affiliated hospital of Harvard Medical School, and one of the three oldest hospitals in the United States. In 2012, hospitals in the United States ranked first (US News&World Report). In 1846, the first anesthetic operation was performed in human history, and X-ray was first used in clinical practice in 1896. Massachusetts General Hospital dominates the largest hospital based research project in the United States, with an annual research funding of more than 600 million dollars. So far, 13 Nobel laureates have been produced

The University of Chicago Medical Center is one of the nation's leading academic medical institutions, home to the University of Chicago, which has been among the top 10 universities in the world for many years, has produced 92 Nobel Prize winners, including 12 in physiology or medicine, and has been at the forefront of global healthcare.

Although the Mayo Clinic in the United States is called a "clinic", it is actually a comprehensive medical center with a long history, the world's first and largest comprehensive, non-profit, group medical institution, and a well deserved medical system brand in the world's medical field.